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๐Ÿ›๏ธ Verified NIH Protocol โ€ข Sourced via U.S. National Library of Medicine (Last Synced: 2026-08-21)

LY4268989 in Adults With Moderately to Severely Active Ulcerative Colitis

๐ŸŸข Recruiting Phase 2 ๐Ÿ’Š Investigational Drug / Biologic Sponsor: Eli Lilly and Company

๐Ÿฉบ Protocol Summary

The main purpose of this study is to evaluate the safety and effectiveness of LY4268989 when compared to placebo in adult participants with moderately to severely active ulcerative colitis (UC). The study drug will be administered orally. The study will last up to approximately 108 weeks, excluding screening.

Primary Research Facility: Valleywise Health Medical Center (Phoenix, Arizona)

๐Ÿ“‹ Basic Study Criteria & Logistics Checklist

0 of 3 Checked

Review these 3 basic logistical and protocol criteria extracted from the public NIH record. (This is a preliminary logistical checklist, not an official clinical eligibility determination).

๐Ÿ“ Primary Site Map

Site: Valleywise Health Medical Center โ€” Phoenix, Arizona

๐Ÿ“ All Participating Trial Locations (259 Sites)

Multi-Center Trial

This protocol is enrolling participants across multiple clinical centers:

1. Valleywise Health Medical Center โ€” Phoenix, Arizona โ€ข Contact: (602) 344-5194
2. One of a Kind Clinical Research Center โ€” Scottsdale, Arizona
3. Clinnova Research โ€” Anaheim, California
4. GMC Clinical Research โ€” Folsom, California
5. Om Research LLC โ€” Temple City, California โ€ข Contact: (661) 388-2239
6. Om Research LLC โ€” Victorville, California โ€ข Contact: (661) 388-2239
7. Peak Gastroenterology Associates โ€” Colorado Springs, Colorado โ€ข Contact: (719) 310-6719
8. Advanced Research Institute - Denver โ€” Denver, Colorado
9. Rocky Mountain Gastroenterology Associates - Lakewood โ€” Lakewood, Colorado
10. Medical Research Center of Connecticut โ€” Hamden, Connecticut
11. K2 Medical Research - Daytona Beach โ€” Daytona Beach, Florida
12. Clinical Research of Osceola โ€” Kissimmee, Florida โ€ข Contact: (407) 954-4016
13. Florida Research Institute โ€” Lakewood Rch, Florida โ€ข Contact: (941) 727-7772
14. AdventHealth Orlando โ€” Orlando, Florida โ€ข Contact: (407) 303-9921
15. Treasure Valley Medical Research โ€” Boise, Idaho โ€ข Contact: (208) 813-6505
16. Grand Teton Research Group โ€” Idaho Falls, Idaho โ€ข Contact: (208) 528-4256
17. Northwestern University โ€” Chicago, Illinois โ€ข Contact: (312) 695-4077
18. Rush University Medical Center โ€” Chicago, Illinois
19. Midwest Digestive Health & Nutrition โ€” Des Plaines, Illinois โ€ข Contact: (312) 767-3244
20. Springfield Clinic - First โ€” Springfield, Illinois โ€ข Contact: (217) 528-7541
21. Gastroenterology Health Partners โ€” New Albany, Indiana โ€ข Contact: (812) 206-1702
22. Gastroenterology Health Partners โ€” Louisville, Kentucky โ€ข Contact: (502) 888-1988
23. GI Alliance - Gastro Group and Endocenter - Mandeville โ€” Mandeville, Louisiana โ€ข Contact: (985) 323-4003
24. Gastroenterology Associates of Western Michigan, PLC d.b.a. West Michigan Clinical Research Center โ€” Wyoming, Michigan
25. Mayo Clinic in Rochester, Minnesota โ€” Rochester, Minnesota

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๐Ÿ’ฐ Clinical Trial Costs & Insurance Coverage

Coverage for clinical trial participation varies depending on your health insurance policy, state legislation, and whether specific procedures are investigational research or routine medical care. Under federal law (Affordable Care Act ยง 2709), health insurers generally cannot drop coverage or refuse to pay for routine patient care costs incurred in approved clinical trials.

๐Ÿ’ก Always ask the study coordinator for the trial's official Informed Consent Form, which outlines all sponsor-funded research items versus procedures billed to your insurance.

๐Ÿ›๏ธ Official Government Provenance

NIH ClinicalTrials.gov Protocol Record

NCT Identifier: NCT07415044 โ€ข Last Synced: 2026-08-21
View on ClinicalTrials.gov โ†—
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