🏛️ Verified NIH Protocol • Sourced via U.S. National Library of Medicine (Last Synced: 2026-07-21)

A Study of Buntanetap in Participants With PD

🟢 Recruiting Phase 2 💊 Investigational Drug / Biologic Sponsor: Annovis Bio Inc.

🩺 Protocol Summary

This study will examine the long-term safety of buntanetap in participants with PD. This will be a 36-month open-label safety study. This study will be conducted with two cohorts. Cohort 1 will enroll via invitation only for PD participants who have previously participated in buntanetap clinical trials. Cohort 2 will be for PD participants who are receiving deep brain stimulation (DBS) treatment. Qualified participants will receive buntanetap 30mg QD after a screening period of up to 42 days.

Primary Research Facility: University of Alabama at Birmingham (Birmingham, Alabama)

📋 Basic Study Criteria & Logistics Checklist

0 of 3 Checked

Review these 3 basic logistical and protocol criteria extracted from the public NIH record. (This is a preliminary logistical checklist, not an official clinical eligibility determination).

Diagnosed with, undergoing evaluation for, or seeking treatment related to Parkinson's Disease (PD)?

🔍 Study Population / Focus Area (Source: Protocol Primary Condition)

Aged between 40 Years and 85 Years?

🔍 Protocol Specified Age Range: 40 Years to 85 Years

Able to attend required in-person clinic visits and study procedures at one of the participating study centers?

🔍 Logistical Requirement: 27 Registered Participating Sites

📍 Primary Site Map

Site: University of Alabama at Birmingham — Birmingham, Alabama

📍 All Participating Trial Locations (27 Sites)

Multi-Center Trial

This protocol is enrolling participants across multiple clinical centers:

1. University of Alabama at Birmingham — Birmingham, Alabama • Contact: (205) 996-4034

2. Banner Sun Health Research Institute - Cleo Roberts Center for Clinical Research — Sun City, Arizona • Contact: (623) 832-6500

3. Parkinson's & Movement Disorder Institute (PMDI) - Orange County Office — Fountain Valley, California • Contact: (714) 378-5074

4. Cenexel Rocky Mountain Clinical Research — Englewood, Colorado • Contact: (720) 776-0092

5. New England Institute for Clinical Research (Ki Health Partners) — Stamford, Connecticut • Contact: (203) 914-1903

6. First Choice Neurology - Aventura Neurologic Associates — Aventura, Florida • Contact: (786) 744-5596

7. Arrow Clinical Trials — Daytona Beach, Florida • Contact: (386) 316-6152

8. Accel Clinical Sites-Georgia LLC dba Accel Research Sites-Lake Oconee CRU — DeLand, Florida • Contact: (386) 785-2400

9. Renstar Medical Research — Ocala, Florida • Contact: (352) 629-5800

10. University of South Florida (USF) - University of South Florida College of Medicine - Parkinson's Di — Tampa, Florida • Contact: (813) 974-8026

11. Conquest Research — Winter Park, Florida • Contact: (407) 916-0060

12. iResearch Atlanta — Decatur, Georgia • Contact: (404) 537-1281

13. Josephson Wallack Munshower Neurology, P.C. — Indianapolis, Indiana • Contact: (317) 573-6061

14. University of Kansas Medical Center (KUMC) - School of Medicine - Parkinson's Disease and Movement D — Kansas City, Kansas • Contact: (913) 588-7159

15. Quest Research Institute — Farmington Hills, Michigan • Contact: (248) 957-8940

16. Mount Sinai Hospital — New York, New York • Contact: (646) 493-1862

17. Duke Department of Neurosurgery — Durham, North Carolina • Contact: (919) 668-3885

18. The Ohio State University Wexner Medical Center — Columbus, Ohio • Contact: (614) 688-8672

19. The Movement Disorder Clinic of Oklahoma — Tulsa, Oklahoma • Contact: (918) 392-4530

20. Abington Neurology — Willow Grove, Pennsylvania • Contact: (215) 957-9250

21. Medical University of South Carolina (MUSC) - The Murray Center for Research on Parkinson's Disease — Charleston, South Carolina • Contact: (843) 792-3223

22. Neurology Clinic, P.C. — Cordova, Tennessee • Contact: (901) 747-1111

23. Veracity Neuroscience LLC — Memphis, Tennessee • Contact: (901) 604-0345

24. Central Texas Neurology — Round Rock, Texas • Contact: (512) 218-1222

25. University of Virginia Health System (UVAHS) - Adult Neurology Clinic — Charlottesville, Virginia • Contact: (434) 982-6599

📄 Print Doctor Discussion Sheet

Preview and print a 1-page summary with 5 tailored questions for your physician.

💰 Clinical Trial Costs & Insurance Coverage

Coverage for clinical trial participation varies depending on your health insurance policy, state legislation, and whether specific procedures are investigational research or routine medical care. Under federal law (Affordable Care Act § 2709), health insurers generally cannot drop coverage or refuse to pay for routine patient care costs incurred in approved clinical trials.

💡 Always ask the study coordinator for the trial's official Informed Consent Form, which outlines all sponsor-funded research items versus procedures billed to your insurance.

🏛️ Official Government Provenance

NIH ClinicalTrials.gov Protocol Record

NCT Identifier: NCT07284784 • Last Synced: 2026-07-21

View on ClinicalTrials.gov ↗