🏛️ Verified NIH Protocol • Sourced via U.S. National Library of Medicine (Last Synced: 2026-07-29)

A Study of the Efficacy and Safety of Lisocabtagene Maraleucel (Liso-cel) as First-Line Therapy in Adults With Transplant-Ineligible Primary Central Nervous System Lymphoma

🟢 Recruiting Phase 2 💊 Investigational Drug / Biologic Sponsor: Juno Therapeutics, Inc., a Bristol-Myers Squibb Company

🩺 Protocol Summary

The purpose of this study is to evaluate the safety and efficacy of lisocabtagene maraleucel (Breyanzi/liso-cel/BMS-986387) in adults as first-line treatment in transplant-ineligible Primary Central Nervous System Lymphoma (PCNSL).

Primary Research Facility: University Of Colorado (Aurora, Colorado)

📋 Basic Study Criteria & Logistics Checklist

0 of 3 Checked

Review these 3 basic logistical and protocol criteria extracted from the public NIH record. (This is a preliminary logistical checklist, not an official clinical eligibility determination).

Diagnosed with, undergoing evaluation for, or seeking treatment related to Lymphoma?

🔍 Study Population / Focus Area (Source: Protocol Primary Condition)

Aged 18 Years or older?

🔍 Protocol Specified Minimum Age: 18 Years

Able to attend required in-person clinic visits and study procedures at one of the participating study centers?

🔍 Logistical Requirement: 40 Registered Participating Sites

📍 Primary Site Map

Site: University Of Colorado — Aurora, Colorado

📍 All Participating Trial Locations (40 Sites)

Multi-Center Trial

This protocol is enrolling participants across multiple clinical centers:

1. University Of Colorado — Aurora, Colorado • Contact: (513) 543-8460

2. Moffitt Cancer Center — Tampa, Florida

3. Robert H. Lurie Comprehensive Cancer Center of Northwestern University — Chicago, Illinois • Contact: (312) 695-0990

4. Dana-Farber Cancer Institute — Boston, Massachusetts • Contact: (617) 632-2166

5. Washington University School of Medicine in St. Louis — St Louis, Missouri • Contact: (314) 454-8323

6. Rutgers Cancer Institute of New Jersey — New Brunswick, New Jersey • Contact: (405) 713-4950

7. Roswell Park Comprehensive Cancer Center — Buffalo, New York

8. Memorial Sloan Kettering Cancer Center — New York, New York • Contact: (646) 608-4132

9. Cleveland Clinic — Cleveland, Ohio • Contact: (216) 445-4782

10. The Ohio State University Comprehensive Cancer Center — Columbus, Ohio

11. University of Pennsylvania — Philadelphia, Pennsylvania • Contact: (215) 662-6933

12. Sarah Cannon Research Institute Oncology Partners — Nashville, Tennessee • Contact: (206) 215-2338

13. MD Anderson Cancer Center — Houston, Texas

14. Fred Hutchinson Cancer Center — Seattle, Washington

15. Local Institution - 0111 — Nice, Alpes-Maritimes

16. Centre Hospitalier Universitaire de Nantes - L' Hopital l'hôtel-Dieu — Nantes, Loire-Atlantique • Contact: +33240083271

17. Local Institution - 0103 — Pierre-Bénite, Rhône

18. CHU de Dijon Bourgogne - Hopital Francois Mitterand — United States • Contact: 3330380295041

19. Chru De Lille - Hopital Claude Huriez — United States • Contact: 33320445713

20. Local Institution - 0112 — United States

21. CHU Montpellier — United States • Contact: +33467338364

22. Local Institution - 0114 — United States

23. Local Institution - 0102 — United States

24. Local Institution - 0108 — United States

25. CHU de Rennes - Hopital de Pontchaillou — United States • Contact: 33299289873

📄 Print Doctor Discussion Sheet

Preview and print a 1-page summary with 5 tailored questions for your physician.

💰 Clinical Trial Costs & Insurance Coverage

Coverage for clinical trial participation varies depending on your health insurance policy, state legislation, and whether specific procedures are investigational research or routine medical care. Under federal law (Affordable Care Act § 2709), health insurers generally cannot drop coverage or refuse to pay for routine patient care costs incurred in approved clinical trials.

💡 Always ask the study coordinator for the trial's official Informed Consent Form, which outlines all sponsor-funded research items versus procedures billed to your insurance.

🏛️ Official Government Provenance

NIH ClinicalTrials.gov Protocol Record

NCT Identifier: NCT07015242 • Last Synced: 2026-07-29

View on ClinicalTrials.gov ↗