Pilot Study of Dose Escalation in Prostate Radiotherapy Using the MR-Linac (DESTINATION-MRL)

🩺 Protocol Summary

This study is a single centre feasibility trial. The trial will recruit men with intermediate risk localised prostate cancer who will all receive targeted dose (escalated/de-escalated dose directed by MRI) 5 fraction SBRT to the prostate. Trial Objectives are: 1. Primary To develop a 5 fraction de-escalated dose SBRT protocol capable of reducing side effects 2. Secondary * To assess levels of acute GU and GI toxicity (CTCAE) * To assess levels of late GU and GI toxicity (CTCAE) * To assess late sexual quality of life (expanded EPIC, IIEF-5) * To assess biochemical relapse-free survival at 2

Primary Research Facility: Sunnybrook Health Sciences Centre (Toronto, Ontario)

Review these 3 basic logistical and protocol criteria extracted from the public NIH record. (This is a preliminary logistical checklist, not an official clinical eligibility determination).

Diagnosed with, undergoing evaluation for, or seeking treatment related to Prostate Cancer?

🔍 Study Population / Focus Area (Source: Protocol Primary Condition)

Aged 18 Years or older? • (Protocol specifies male participants only)

🔍 Protocol Specified Minimum Age: 18 Years

Able to attend required clinic visits at Sunnybrook Health Sciences Centre (Toronto, Ontario)?

🔍 Logistical Requirement: Site at Sunnybrook Health Sciences Centre

📍 Primary Site Map

Site: Sunnybrook Health Sciences Centre — Toronto, Ontario

💰 Clinical Trial Costs & Insurance Coverage

Coverage for clinical trial participation varies depending on your health insurance policy, state legislation, and whether specific procedures are investigational research or routine medical care. Under federal law (Affordable Care Act § 2709), health insurers generally cannot drop coverage or refuse to pay for routine patient care costs incurred in approved clinical trials.

💡 Always ask the study coordinator for the trial's official Informed Consent Form, which outlines all sponsor-funded research items versus procedures billed to your insurance.