🏛️ Verified NIH Protocol • Sourced via U.S. National Library of Medicine (Last Synced: 2026-08-27)

Sacituzumab Tirumotecan (MK-2870) in Combination With Pembrolizumab Versus Pembrolizumab Alone in Metastatic Non-small Cell Lung Cancer (NSCLC) With Programmed Cell Death Ligand 1 (PD-L1) Tumor Proportion Score (TPS) ≥ 50% (MK-2870-007)

🟢 Recruiting Phase 3 💊 Investigational Drug / Biologic Sponsor: Merck Sharp & Dohme LLC

🩺 Protocol Summary

The primary objective of the study is to compare sacituzumab tirumotecan combined with pembrolizumab to pembrolizumab alone with respect to overall survival (OS). The primary hypothesis is that the combination of sacituzumab tirumotecan and pembrolizumab is superior to pembrolizumab alone with respect to OS.

Primary Research Facility: Mayo Clinic in Arizona - Phoenix ( Site 0147) (Phoenix, Arizona)

📋 Preliminary Self-Screener

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Answer all 3 basic criteria below to see your preliminary screening result:

Diagnosed with or currently undergoing clinical evaluation for **Carcinoma, Non-Small-Cell Lung**?

Aged **18 Years or older**?

Able to attend study appointments at **Mayo Clinic in Arizona - Phoenix ( Site 0147)** (Phoenix, Arizona) or affiliated sites?

📍 Primary Site Map

Site: Mayo Clinic in Arizona - Phoenix ( Site 0147) — Phoenix, Arizona

📍 All Participating Trial Locations (220 Sites)

Multi-Center Trial

This protocol is enrolling participants across multiple clinical centers:

1. Mayo Clinic in Arizona - Phoenix ( Site 0147) — Phoenix, Arizona • Contact: (480) 342-4800

2. Roy and Patricia Disney Family Cancer Center - Providence Saint Joseph Medical Center ( Site 0130) — Burbank, California • Contact: (818) 840-0921

3. Cancer Centers of Colorado St. Mary's Regional Hospital ( Site 0132) — Grand Junction, Colorado • Contact: (970) 298-7638

4. Mayo Clinic in Florida-Mayo Clinic Comprehensive Cancer Center ( Site 0133) — Jacksonville, Florida • Contact: (904) 953-9945

5. Northwest Georgia Oncology Centers, a Service of Wellstar Cobb Hospital-Research ( Site 0106) — Marietta, Georgia

6. The University of Louisville, James Graham Brown Cancer Center ( Site 0121) — Louisville, Kentucky

7. New England Cancer Specialists ( Site 0143) — Westbrook, Maine • Contact: (207) 303-3424

8. University of Massachusetts Chan Medical School-Division of Hematology/Oncology ( Site 0144) — Worcester, Massachusetts

9. Allina Health Cancer Institute - Abbott Northwestern Hospital ( Site 0115) — Minneapolis, Minnesota • Contact: (651) 241-7025

10. Mayo Clinic - Rochester ( Site 0148) — Rochester, Minnesota • Contact: (507) 538-1665

11. Hattiesburg Clinic Hematology/Oncology ( Site 0104) — Hattiesburg, Mississippi • Contact: (601) 261-1700

12. Renown Regional Medical Center-Renown Health Medical Oncology ( Site 0134) — Reno, Nevada • Contact: (775) 982-5050

13. University Hospitals Cleveland Medical Center ( Site 0119) — Cleveland, Ohio

14. Good Samaritan Regional Medical Center-Samaritan Pastega Regional Cancer Center ( Site 0117) — Corvallis, Oregon • Contact: (541) 768-4950

15. Oncology Consultants P.A. ( Site 0129) — Houston, Texas

16. Instituto Alexander Fleming ( Site 0306) — Ciudad Autónoma de Buenos Aires, Buenos Aires • Contact: +54 9 011-3221-8900

17. Hospital Británico de Buenos Aires-Oncology ( Site 0304) — Buenos Aires, Buenos Aires F.D. • Contact: +541143096807

18. Centro Privado de RMI Río Cuarto S.A. II ( Site 0310) — Río Cuarto, Córdoba Province • Contact: +54351153819050

19. Instituto de Oncología de Rosario ( Site 0301) — Rosario, Santa Fe Province • Contact: +549-341-5778394

20. Hospital Aleman-Oncology ( Site 0300) — United States • Contact: +541148277000

21. Port Macquarie - Mid North Coast Cancer Institute-Medical Oncology ( Site 3002) — Port Macquarie, New South Wales • Contact: +61265801820

22. Westmead Hospital ( Site 3000) — Westmead, New South Wales • Contact: +61247343500

23. Grampians Health-Medical Oncology ( Site 3001) — Ballarat Central, Victoria

24. Northern Hospital ( Site 3003) — Epping, Victoria • Contact: +61384058715

25. Peninsula University Hospital ( Site 3004) — Frankston, Victoria • Contact: +61397847175

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💰 Clinical Trial Costs & Insurance Coverage

Coverage for clinical trial participation varies depending on your health insurance policy, state legislation, and whether specific procedures are investigational research or routine medical care. Under federal law (Affordable Care Act § 2709), health insurers generally cannot drop coverage or refuse to pay for routine patient care costs incurred in approved clinical trials.

💡 Always ask the study coordinator for the trial's official Informed Consent Form, which outlines all sponsor-funded research items versus procedures billed to your insurance.

🏛️ Official Government Provenance

NIH ClinicalTrials.gov Protocol Record

NCT Identifier: NCT06170788 • Last Synced: 2026-08-27

View on ClinicalTrials.gov ↗