🏛️ Verified NIH Protocol • Sourced via U.S. National Library of Medicine (Last Synced: 2026-04-28)

The Canadian CABG or PCI in Patients With Ischemic Cardiomyopathy Trial (STICH3C)

🟢 Recruiting Protocol / Phase N/A 🩺 Clinical Procedure Protocol Sponsor: Sunnybrook Health Sciences Centre

🩺 Protocol Summary

The Canadian CABG or PCI in Patients With Ischemic Cardiomyopathy (STICH3C) trial is a prospective, unblinded, international multi-center randomized trial of 754 subjects enrolled in approximately 45 centers comparing revascularization by percutaneous coronary intervention (PCI) vs. coronary artery bypass grafting (CABG) in patients with multivessel/left main (LM) coronary artery disease (CAD) and reduced left ventricular ejection fraction (LVEF). The primary objective is to determine whether CABG compared to PCI is associated with a reduction in all-cause death, stroke, spontaneous myocardial infarction (MI), urgent repeat revascularization (RR), or heart failure (HF) readmission over a median follow-up of 5 years in patients with multivessel/LM CAD and ischemic left ventricular dysfunction (iLVSD). Eligible patients are considered by the local Heart Team appropriate and amenable for non-emergent revascularization by both modes of revascularization. The secondary objectives are to describe the early risks of both procedures, and a comprehensive set of patient-reported outcomes longitudinally.

Primary Research Facility: Cedars-Sinai (Los Angeles, California)

📋 Basic Study Criteria & Logistics Checklist

0 of 3 Checked

Review these 3 basic logistical and protocol criteria extracted from the public NIH record. (This is a preliminary logistical checklist, not an official clinical eligibility determination).

Diagnosed with, undergoing evaluation for, or seeking treatment related to Coronary Artery Disease?

🔍 Study Population / Focus Area (Source: Protocol Primary Condition)

Aged 18 Years or older?

🔍 Protocol Specified Minimum Age: 18 Years

Able to attend required in-person clinic visits and study procedures at one of the participating study centers?

🔍 Logistical Requirement: 43 Registered Participating Sites

📍 Primary Site Map

Site: Cedars-Sinai — Los Angeles, California

📍 All Participating Trial Locations (43 Sites)

Multi-Center Trial

This protocol is enrolling participants across multiple clinical centers:

1. Cedars-Sinai — Los Angeles, California

2. Yale University — New Haven, Connecticut

3. UofL Health, Inc — Louisville, Kentucky

4. John Hopkins Hospital — Baltimore, Maryland

5. Mayo Clinic — Rochester, Minnesota

6. University Hospitals Cleveland Medical Center — Cleveland, Ohio

7. Medical University of Vienna — United States

8. Heart Institute, Medical School of the University of Sao Paulo_INCOR — United States

9. University of Calgary; Libin Cardiovascular Institute — Calgary, Alberta

10. Mackenzie Health Sciences Center — Edmonton, Alberta

11. Fraser Health; Royal Columbian Hospital — New Westminster, British Columbia

12. Providence Health — Vancouver, British Columbia

13. The University of Manitoba and St. Boniface Hospital Inc. — Winnipeg, Manitoba

14. Queen Elizabeth II Hospital — Halifax, Nova Scotia

15. Hamilton General Hospital — Hamilton, Ontario

16. London Health Sciences Center, University Hospital — London, Ontario

17. Southlake Regional HC — Newmarket, Ontario

18. Ottawa Heart Institute — Ottawa, Ontario

19. Sunnybrook Health Sciences Center — Toronto, Ontario • Contact: (416) 480-6100

20. St. Michael's — Toronto, Ontario

21. Toronto General Hospital — Toronto, Ontario

22. Center Hospitalier Universitaire de Montreal — Montreal, Quebec

23. Montreal Heart Institute — Montreal, Quebec • Contact: (514) 376-3330

24. Hospital Sacre-Coeur — Montreal, Quebec

25. Institut de Cardiologie Quebec (QC) - Laval — Québec, Quebec

📄 Print Doctor Discussion Sheet

Preview and print a 1-page summary with 5 tailored questions for your physician.

💰 Clinical Trial Costs & Insurance Coverage

Coverage for clinical trial participation varies depending on your health insurance policy, state legislation, and whether specific procedures are investigational research or routine medical care. Under federal law (Affordable Care Act § 2709), health insurers generally cannot drop coverage or refuse to pay for routine patient care costs incurred in approved clinical trials.

💡 Always ask the study coordinator for the trial's official Informed Consent Form, which outlines all sponsor-funded research items versus procedures billed to your insurance.

🏛️ Official Government Provenance

NIH ClinicalTrials.gov Protocol Record

NCT Identifier: NCT05427370 • Last Synced: 2026-04-28

View on ClinicalTrials.gov ↗