Trial to Determine Effective Aspirin Dose in COPD

🩺 Protocol Summary

Chronic obstructive pulmonary disease (COPD) is the fourth leading cause of death in the United States. Current treatments for COPD focus on inhaler therapies that do not address manifestations of the disease on other organ systems. Platelets, which are small blood cells that typically help with clotting, are also involved in generalized inflammation and dysfunctionality of immune cells when these cells become activated. Activated platelets have long been known to play a role in the development of cardiovascular disease. However, there is recent evidence that activated platelets may be involved in worse respiratory symptoms in COPD independent of cardiovascular disease. Individuals with COPD who are taking aspirin, which is an antiplatelet agent that blocks activation of platelets, have been shown to have improved respiratory symptoms, fewer COPD flares, and lower mortality. The investigators' ultimate goal is to study whether aspirin use improves respiratory symptoms independent of cardiovascular disease. The investigators are conducting the current pilot trial to determine the optimal dose of aspirin that blocks platelet activation in this population and investigate whether there are any blood or urine tests that can help with understanding response to therapy. The results will inform the design of a larger trial investigating clinical outcomes. The investigators hypothesize that daily low-dose aspirin will not be sufficient to adequately suppress platelet activation and that an aspirin dose of at least 162mg daily will be necessary.

Primary Research Facility: Johns Hopkins Bayview Medical Center (Baltimore, Maryland)

Review these 3 basic logistical and protocol criteria extracted from the public NIH record. (This is a preliminary logistical checklist, not an official clinical eligibility determination).

Diagnosed with, undergoing evaluation for, or seeking treatment related to Pulmonary Disease, Chronic Obstructive?

🔍 Study Population / Focus Area (Source: Protocol Primary Condition)

Aged between 40 Years and 80 Years?

🔍 Protocol Specified Age Range: 40 Years to 80 Years

Able to attend required clinic visits at Johns Hopkins Bayview Medical Center (Baltimore, Maryland)?

🔍 Logistical Requirement: Site at Johns Hopkins Bayview Medical Center

📍 Primary Site Map

Site: Johns Hopkins Bayview Medical Center — Baltimore, Maryland

💰 Clinical Trial Costs & Insurance Coverage

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💡 Always ask the study coordinator for the trial's official Informed Consent Form, which outlines all sponsor-funded research items versus procedures billed to your insurance.