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🏛️ Verified NIH Protocol • Sourced via U.S. National Library of Medicine (Last Synced: 2026-04-24)

WithHolding Enteral Feeds Around Blood Transfusion (International)

🟢 Recruiting Protocol / Phase N/A 📋 Clinical Research Protocol Sponsor: IWK Health Centre

🩺 Protocol Summary

The WHEAT International trial is a comparative effectiveness trial exploring whether withholding enteral feeds around the time of blood transfusion in very premature infants (\<30 weeks) will reduce the occurrence of Necrotizing Enterocolitis (NEC). Currently both continued feeding and withholding feeding are approved care practices. The current study will randomize infants from Neonatal Intensive Care Units (NICUs) across Canada and the United Kingdom (UK) into one of the two care approaches (withholding or continued feeds) to determine if any significant outcomes are found.

Primary Research Facility: IWK Health (Halifax, Nova Scotia)

📋 Basic Study Criteria & Logistics Checklist

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Review these 3 basic logistical and protocol criteria extracted from the public NIH record. (This is a preliminary logistical checklist, not an official clinical eligibility determination).

📍 Primary Site Map

Site: IWK Health — Halifax, Nova Scotia

📍 All Participating Trial Locations (40 Sites)

Multi-Center Trial

This protocol is enrolling participants across multiple clinical centers:

1. IWK Health — Halifax, Nova Scotia • Contact: (902) 470-6630
2. Norfolk & Norwich University Hospitals NHS Foundation Trust (Norfolk & Norwich University Hospital) — Norwich, England
3. The Hillingdon Hospitals NHS Foundation Trust (Hillingdon Hospital) — Hillingdon, UK
4. Barts Health NHS Trust (3 Hospitals: Royal London Hospital, Whipps Cross Hospital, Newham General Hospital) — London, UK
5. Chelsea and Westminster Hospital NHS Foundation Trust (Chelsea and Westminster Hospital) — London, UK
6. Imperial College Healthcare NHS Trust (2 Hospitals: St Mary's Hospital & Queen Charlotte's and Chelsea Hospital) — London, UK
7. Bedfordshire Hospitals NHS Foundation Trust (Luton & Dunstable University Hospital) — Luton, UK
8. East Kent University Hospitals NHS Foundation Trust (William Harvey Hospital) — United States
9. Buckinghamshire Healthcare NHS Trust (Stoke Mandeville Hospital) — United States
10. Barnsley Hospital NHS Foundation Trust — United States
11. Birmingham Women's and Children's NHS Foundation Trust (Birmingham Women's Hospital NICU) — United States
12. University Hospitals Birmingham NHS Trust (2 Hospitals: Heartland's Hospital & Good Hope Hospital) — United States
13. Bradford Teaching Hospitals NHS Foundation Trust (Bradford Royal Infirmary) — United States
14. North Bristol NHS Trust (Southmead Hospital) — United States
15. East and North Essex NHS Foundation Trust - Colchester Hospital — United States
16. University Hospital Coventry & Warwickshire NHS Trust (University Hospital Coventry) — United States
17. University Hospitals of Derby and Burton NHS Trust (Royal Derby Hospital) — United States
18. NHS Tayside (Ninewells Hospital) — United States
19. Medway Hospital NHS Foundation Trust (Oliver Fisher Neonatal Unit, Medway Maritime Hospital) — United States
20. Gloucestershire Hospitals NHS Foundation Trust (Gloucestershire Royal Hospital) — United States
21. Calderdale & Huddersfield NHS Foundation Trust (Calderdale Royal Hospital) — United States
22. East and North Essex NHS Foundation Trust - Ipswich Hospital — United States
23. Leeds Teaching Hospitals NHS Trust (Leeds General Infirmary & St James' University Hospital) — United States
24. University Hospitals of Leicester NHS Trust (Leicester Royal Infirmary) — United States
25. Liverpool Women's Hospital NHS Foundation Trust (Liverpool Women's Hospital) — United States

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💰 Clinical Trial Costs & Insurance Coverage

Coverage for clinical trial participation varies depending on your health insurance policy, state legislation, and whether specific procedures are investigational research or routine medical care. Under federal law (Affordable Care Act § 2709), health insurers generally cannot drop coverage or refuse to pay for routine patient care costs incurred in approved clinical trials.

💡 Always ask the study coordinator for the trial's official Informed Consent Form, which outlines all sponsor-funded research items versus procedures billed to your insurance.

🏛️ Official Government Provenance

NIH ClinicalTrials.gov Protocol Record

NCT Identifier: NCT05213806 • Last Synced: 2026-04-24
View on ClinicalTrials.gov ↗
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