Extracorporeal Photopheresis in Sezary Syndrome

🩺 Protocol Summary

The primary endpoint is to determine if ECP induces a decrease in % of tumor cells after treatment. 20 patients with Sezary Syndrome will receive ECP weekly x4, then bi-weekly for 5 months. Each patient will donate 5 samples to determine immune responses in peripheral blood. Additional clinical assessments will be a modified skin weighted assessment and flow cytometry at baseline and months 3 and 6. A CT scan will be obtained at baseline and only repeated if pathology is present at baseline. The tumor microenvironment will be studied by comparing transcriptomics of the blood samples before, 1 day after first ECP treatment, cycle 1, 1, 3 and 6 months after ECP treatment by scRNAseq (5 samples total per patient ).

Primary Research Facility: Emory University School of Medicine (Atlanta, Georgia)

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📍 Primary Site Map

Site: Emory University School of Medicine — Atlanta, Georgia

This protocol is enrolling participants across multiple clinical centers:

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