🏛️ Verified NIH Protocol • Sourced via U.S. National Library of Medicine (Last Synced: 2026-06-22)

Prevention of Persistent Pain With LidocAine iNfusions in Breast Cancer Surgery (PLAN)

🟢 Recruiting Phase 3 💊 Investigational Drug / Biologic Sponsor: University Health Network, Toronto

🩺 Protocol Summary

Phase III, international multicentre, parallel group, blinded, 1:1 randomized controlled trial to determine the effect of an intraoperative intravenous lidocaine infusion on reducing the development of persistent pain 3-months after breast cancer surgery.

Primary Research Facility: Foothills Medical Centre (Calgary, Alberta)

📋 Preliminary Self-Screener

0 of 3 Answered

Answer all 3 basic criteria below to see your preliminary screening result:

Diagnosed with or currently undergoing clinical evaluation for **Breast Neoplasms**?

Aged between **18 Years** and **100 Years**?

Able to attend study appointments at **Foothills Medical Centre** (Calgary, Alberta) or affiliated sites?

📍 Primary Site Map

Site: Foothills Medical Centre — Calgary, Alberta

📍 All Participating Trial Locations (17 Sites)

Multi-Center Trial

This protocol is enrolling participants across multiple clinical centers:

1. Foothills Medical Centre — Calgary, Alberta

2. Sturgeon Community Hospital — Edmonton, Alberta

3. Eastern Health- Health Sciences Centre — St. John's, Newfoundland and Labrador

4. IWK — Halifax, Nova Scotia

5. Juravinski Hospital — Hamilton, Ontario

6. North York General Hospital — North York, Ontario

7. The Ottawa Hospital — Ottawa, Ontario

8. Thunder Bay Regional Health Sciences Centre — Thunder Bay, Ontario

9. Humber River Hospital — Toronto, Ontario

10. Mount Sinai Hospital — Toronto, Ontario

11. St. Michael's Hospital — Toronto, Ontario

12. Sunnybrook Health Sciences Centre — Toronto, Ontario

13. University Health Network — Toronto, Ontario

14. Women's College Hospital — Toronto, Ontario

15. Hôpital Maisonneuve-Rosemont — Montreal, Quebec

16. B.P. Koirala Institute of Health Sciences — United States

17. Obafemi Awolowo University Teaching Hospitals Complex — United States

📄 Print Doctor Discussion Sheet

Preview and print a 1-page summary with 5 tailored questions for your physician.

💰 Clinical Trial Costs & Insurance Coverage

Coverage for clinical trial participation varies depending on your health insurance policy, state legislation, and whether specific procedures are investigational research or routine medical care. Under federal law (Affordable Care Act § 2709), health insurers generally cannot drop coverage or refuse to pay for routine patient care costs incurred in approved clinical trials.

💡 Always ask the study coordinator for the trial's official Informed Consent Form, which outlines all sponsor-funded research items versus procedures billed to your insurance.

🏛️ Official Government Provenance

NIH ClinicalTrials.gov Protocol Record

NCT Identifier: NCT04874038 • Last Synced: 2026-06-22

View on ClinicalTrials.gov ↗