🏛️ Verified NIH Protocol • Sourced via U.S. National Library of Medicine (Last Synced: 2025-12-17)

Investigation of Metformin in Pre-Diabetes on Atherosclerotic Cardiovascular OuTcomes

🟢 Recruiting Phase 4 💊 Investigational Drug / Biologic Sponsor: VA Office of Research and Development

🩺 Protocol Summary

This research will help us to learn if the medicine called metformin reduces the risk of death, heart attacks, and/or strokes in Veterans who have pre-diabetes and heart or blood vessel problems.

Primary Research Facility: Phoenix VA Health Care System, Phoenix, AZ (Phoenix, Arizona)

📋 Basic Study Criteria & Logistics Checklist

0 of 3 Checked

Review these 3 basic logistical and protocol criteria extracted from the public NIH record. (This is a preliminary logistical checklist, not an official clinical eligibility determination).

Diagnosed with, undergoing evaluation for, or seeking treatment related to Prediabetic State?

🔍 Study Population / Focus Area (Source: Protocol Primary Condition)

Aged 18 Years or older?

🔍 Protocol Specified Minimum Age: 18 Years

Able to attend required in-person clinic visits and study procedures at one of the participating study centers?

🔍 Logistical Requirement: 40 Registered Participating Sites

📍 Primary Site Map

Site: Phoenix VA Health Care System, Phoenix, AZ — Phoenix, Arizona

📍 All Participating Trial Locations (40 Sites)

Multi-Center Trial

This protocol is enrolling participants across multiple clinical centers:

1. Phoenix VA Health Care System, Phoenix, AZ — Phoenix, Arizona

2. Southern Arizona VA Health Care System, Tucson, AZ — Tucson, Arizona • Contact: (520) 792-1450

3. Central Arkansas VHS John L. McClellan Memorial Veterans Hospital, Little Rock, AR — Little Rock, Arkansas • Contact: (501) 257-5808

4. VA Loma Linda Healthcare System, Loma Linda, CA — Loma Linda, California • Contact: (909) 825-7084

5. VA Long Beach Healthcare System, Long Beach, CA — Long Beach, California • Contact: (562) 826-3497

6. VA Palo Alto Health Care System, Palo Alto, CA — Palo Alto, California • Contact: (650) 493-5000

7. VA San Diego Healthcare System, San Diego, CA — San Diego, California • Contact: (858) 552-8585

8. VA Greater Los Angeles Healthcare System, West Los Angeles, CA — West Los Angeles, California • Contact: (310) 478-3711

9. Rocky Mountain Regional VA Medical Center, Aurora, CO — Aurora, Colorado • Contact: (415) 254-3563

10. VA Connecticut Healthcare System West Haven Campus, West Haven, CT — West Haven, Connecticut • Contact: (203) 932-5711

11. Bay Pines VA Healthcare System, Pay Pines, FL — Bay Pines, Florida • Contact: (727) 398-6661

12. North Florida/South Georgia Veterans Health System, Gainesville, FL — Gainesville, Florida • Contact: (352) 376-1611

13. Miami VA Healthcare System, Miami, FL — Miami, Florida • Contact: (305) 926-3780

14. Atlanta VA Medical and Rehab Center, Decatur, GA — Decatur, Georgia • Contact: (404) 321-6111

15. VA Pacific Islands Health Care System, Honolulu, HI — Honolulu, Hawaii • Contact: (808) 433-7643

16. Jesse Brown VA Medical Center, Chicago, IL — Chicago, Illinois

17. Edward Hines Jr. VA Hospital, Hines, IL — Hines, Illinois • Contact: (708) 202-8387

18. Iowa City VA Health Care System, Iowa City, IA — Iowa City, Iowa • Contact: (319) 353-8622

19. Lexington VA Medical Center, Lexington, KY — Lexington, Kentucky • Contact: (859) 233-4511

20. Rehabilitation R&D Service, Baltimore, MD — Baltimore, Maryland • Contact: (410) 605-7000

21. VA Boston Healthcare System Jamaica Plain Campus, Jamaica Plain, MA — Boston, Massachusetts • Contact: (857) 203-6840

22. Minneapolis VA Health Care System, Minneapolis, MN — Minneapolis, Minnesota • Contact: (612) 467-3655

23. Kansas City VA Medical Center, Kansas City, MO — Kansas City, Missouri • Contact: (914) 886-3866

24. Omaha VA Nebraska-Western Iowa Health Care System, Omaha, NE — Omaha, Nebraska • Contact: (402) 346-8800

25. New Mexico VA Health Care System, Albuquerque, NM — Albuquerque, New Mexico • Contact: (505) 265-1711

📄 Print Doctor Discussion Sheet

Preview and print a 1-page summary with 5 tailored questions for your physician.

💰 Clinical Trial Costs & Insurance Coverage

Coverage for clinical trial participation varies depending on your health insurance policy, state legislation, and whether specific procedures are investigational research or routine medical care. Under federal law (Affordable Care Act § 2709), health insurers generally cannot drop coverage or refuse to pay for routine patient care costs incurred in approved clinical trials.

💡 Always ask the study coordinator for the trial's official Informed Consent Form, which outlines all sponsor-funded research items versus procedures billed to your insurance.

🏛️ Official Government Provenance

NIH ClinicalTrials.gov Protocol Record

NCT Identifier: NCT02915198 • Last Synced: 2025-12-17

View on ClinicalTrials.gov ↗