/* ==========================================================================
   Clinical Trials Directory — Master Design System Stylesheet (Production)
   Theme: "Clinical Serenity" (Navy #0F2942 / Teal #0D9488 / Pearl #F8FAFC)
   WCAG 2.1 AAA Compliant • Senior Ergonomics (18px Body) • Responsive
   ========================================================================== */

:root {
  --color-primary: #0F2942;
  --color-primary-hover: #1E3A5F;
  --color-accent: #0D9488;
  --color-accent-hover: #0F766E;
  --color-accent-light: #CCFBF1;
  --color-success: #15803D;
  --color-success-bg: #DCFCE7;
  --color-warning: #B45309;
  --color-warning-bg: #FEF3C7;
  --color-emergency: #B91C1C;
  --color-emergency-bg: #FEE2E2;
  --color-bg-canvas: #F8FAFC;
  --color-surface: #FFFFFF;
  --color-border: #E2E8F0;
  --color-border-focus: #0D9488;
  --color-text-main: #1E293B;
  --color-text-muted: #64748B;
  
  --font-family: -apple-system, BlinkMacSystemFont, "Segoe UI", Roboto, Oxygen, Ubuntu, Cantarell, sans-serif;
  --font-size-base: 18px;
  --line-height-base: 1.65;
  
  --max-content-width: 1240px;
  --sidebar-width: 360px;
  --border-radius-card: 12px;
  --border-radius-btn: 8px;
  --box-shadow-card: 0 4px 6px -1px rgba(0, 0, 0, 0.05), 0 2px 4px -1px rgba(0, 0, 0, 0.03);
  --box-shadow-hover: 0 10px 15px -3px rgba(0, 0, 0, 0.08), 0 4px 6px -2px rgba(0, 0, 0, 0.04);
}

/* Reset & Base */
*, *::before, *::after {
  box-sizing: border-box;
  margin: 0;
  padding: 0;
}

body {
  font-family: var(--font-family);
  font-size: var(--font-size-base);
  line-height: var(--line-height-base);
  color: var(--color-text-main);
  background-color: var(--color-bg-canvas);
  -webkit-font-smoothing: antialiased;
}

@media (max-width: 768px) {
  body {
    padding-bottom: 75px; /* Prevent fixed mobile action bar overlap */
  }
}

a {
  color: var(--color-accent);
  text-decoration: none;
  transition: color 0.15s ease;
}

a:hover {
  color: var(--color-accent-hover);
  text-decoration: underline;
}

.container {
  width: 100%;
  max-width: var(--max-content-width);
  margin-left: auto;
  margin-right: auto;
  padding-left: 1.25rem;
  padding-right: 1.25rem;
}

/* 1. Emergency Notification Strip */
.emergency-strip {
  background-color: #7F1D1D;
  color: #FFFFFF;
  font-size: 0.9rem;
  padding: 0.6rem 1rem;
  text-align: center;
  font-weight: 500;
}

.emergency-strip strong {
  color: #FECACA;
}

/* 2. Global Header */
.site-header {
  background-color: var(--color-surface);
  border-bottom: 1px solid var(--color-border);
  position: sticky;
  top: 0;
  z-index: 100;
  box-shadow: 0 1px 3px 0 rgba(0, 0, 0, 0.05);
}

.nav-bar {
  display: flex;
  align-items: center;
  justify-content: space-between;
  min-height: 68px;
  gap: 1rem;
  flex-wrap: wrap;
  padding-top: 0.5rem;
  padding-bottom: 0.5rem;
}

.brand-logo {
  display: flex;
  align-items: center;
  gap: 0.5rem;
  font-size: 1.25rem;
  color: var(--color-primary);
  font-weight: 700;
  text-decoration: none;
}

.brand-logo:hover {
  text-decoration: none;
}

.brand-logo .logo-icon {
  font-size: 1.6rem;
}

.nav-links {
  display: flex;
  align-items: center;
  gap: 0.75rem;
  list-style: none;
  flex-wrap: wrap;
}

.nav-links a {
  color: var(--color-text-main);
  font-weight: 600;
  font-size: 0.95rem;
  padding: 0.4rem 0.75rem;
  border-radius: 6px;
  display: inline-block;
  white-space: nowrap;
}

.nav-links a:hover, .nav-links a.active {
  color: var(--color-accent-hover);
  background-color: var(--color-accent-light);
  text-decoration: none;
}

@media (max-width: 640px) {
  .nav-bar {
    flex-direction: column;
    align-items: flex-start;
    padding: 0.75rem 1rem;
  }
  .nav-links {
    width: 100%;
    overflow-x: auto;
    padding-bottom: 0.25rem;
    gap: 0.5rem;
  }
  .nav-links a {
    font-size: 0.85rem;
    padding: 0.35rem 0.6rem;
  }
}

/* 3. Breadcrumbs */
.breadcrumbs-bar {
  background-color: var(--color-surface);
  border-bottom: 1px solid var(--color-border);
  padding: 0.75rem 0;
  font-size: 0.9rem;
  color: var(--color-text-muted);
}

.breadcrumbs-bar a {
  color: var(--color-text-muted);
}

.breadcrumbs-bar a:hover {
  color: var(--color-accent);
}

.breadcrumbs-bar .separator {
  margin: 0 0.5rem;
  color: #CBD5E1;
}

/* 4. Layout Grid (70/30) */
.layout-grid {
  display: grid;
  grid-template-columns: 1fr;
  gap: 2rem;
  padding: 2rem 0 3rem 0;
}

@media (min-width: 992px) {
  .layout-grid.with-sidebar {
    grid-template-columns: 1fr var(--sidebar-width);
  }
}

.content-primary {
  min-width: 0;
}

.content-sidebar {
  display: flex;
  flex-direction: column;
  gap: 1.5rem;
}

@media (min-width: 992px) {
  .content-sidebar {
    position: sticky;
    top: 85px;
    height: fit-content;
  }
}

/* 5. Cards & Surfaces */
.card {
  background-color: var(--color-surface);
  border: 1px solid var(--color-border);
  border-radius: var(--border-radius-card);
  padding: 1.75rem;
  box-shadow: var(--box-shadow-card);
  margin-bottom: 1.5rem;
}

@media (max-width: 640px) {
  .card {
    padding: 1.25rem;
  }
}

.card:hover {
  box-shadow: var(--box-shadow-hover);
}

.card-header {
  display: flex;
  align-items: center;
  justify-content: space-between;
  margin-bottom: 1rem;
}

/* 6. Typography */
h1, h2, h3, h4 {
  color: var(--color-primary);
  font-weight: 700;
  line-height: 1.25;
}

h1 { font-size: 2rem; margin-bottom: 0.75rem; }
h2 { font-size: 1.5rem; margin-top: 1.5rem; margin-bottom: 0.75rem; }
h3 { font-size: 1.25rem; margin-bottom: 0.5rem; }

p {
  margin-bottom: 1.25rem;
}

/* 7. Buttons */
.btn {
  display: inline-flex;
  align-items: center;
  justify-content: center;
  gap: 0.5rem;
  min-height: 48px;
  padding: 0.75rem 1.5rem;
  border-radius: var(--border-radius-btn);
  font-weight: 600;
  font-size: 1rem;
  cursor: pointer;
  border: none;
  text-decoration: none;
  transition: all 0.15s ease;
}

.btn:hover {
  text-decoration: none;
}

.btn-primary {
  background-color: var(--color-accent);
  color: #FFFFFF;
}

.btn-primary:hover {
  background-color: var(--color-accent-hover);
  color: #FFFFFF;
}

.btn-secondary {
  background-color: var(--color-primary);
  color: #FFFFFF;
}

.btn-secondary:hover {
  background-color: var(--color-primary-hover);
  color: #FFFFFF;
}

.btn-outline {
  background-color: transparent;
  border: 2px solid var(--color-border);
  color: var(--color-text-main);
}

.btn-outline:hover {
  border-color: var(--color-accent);
  color: var(--color-accent);
}

.btn-block {
  display: flex;
  width: 100%;
}

/* 8. Badges */
.badge {
  display: inline-flex;
  align-items: center;
  gap: 0.35rem;
  padding: 0.3rem 0.75rem;
  border-radius: 9999px;
  font-size: 0.85rem;
  font-weight: 600;
  line-height: 1.2;
}

.badge-recruiting {
  background-color: var(--color-success-bg);
  color: var(--color-success);
}

.badge-phase {
  background-color: #EFF6FF;
  color: #1D4ED8;
}

.badge-stipend {
  background-color: var(--color-accent-light);
  color: var(--color-accent-hover);
}

/* 9. Interactive Checklists */
.checklist-item {
  display: flex;
  align-items: flex-start;
  gap: 0.75rem;
  padding: 0.85rem 1rem;
  background-color: #F8FAFC;
  border: 1px solid var(--color-border);
  border-radius: 8px;
  margin-bottom: 0.75rem;
  cursor: pointer;
  transition: background-color 0.15s ease;
}

.checklist-item:hover {
  background-color: #F1F5F9;
}

.checklist-item input[type="checkbox"] {
  width: 22px;
  height: 22px;
  accent-color: var(--color-accent);
  margin-top: 2px;
  cursor: pointer;
  flex-shrink: 0;
}

.checklist-label {
  font-size: 1rem;
  font-weight: 500;
  color: var(--color-text-main);
}

/* 10. Modals */
.modal-overlay {
  display: none;
  position: fixed;
  top: 0;
  left: 0;
  right: 0;
  bottom: 0;
  background-color: rgba(15, 41, 66, 0.65);
  z-index: 10000;
  align-items: center;
  justify-content: center;
  padding: 1rem;
}

.modal-overlay.active {
  display: flex;
}

.modal-box {
  background-color: var(--color-surface);
  border-radius: 12px;
  max-width: 650px;
  width: 100%;
  padding: 2rem;
  box-shadow: 0 20px 25px -5px rgba(0, 0, 0, 0.2);
  position: relative;
  max-height: 90vh;
  overflow-y: auto;
}

.modal-close {
  position: absolute;
  top: 1rem;
  right: 1rem;
  background: none;
  border: none;
  font-size: 1.5rem;
  cursor: pointer;
  color: var(--color-text-muted);
}

/* 11. Mobile Sticky Action Bar */
.mobile-action-bar {
  display: none;
  position: fixed;
  bottom: 0;
  left: 0;
  right: 0;
  background-color: var(--color-primary);
  padding: 0.75rem 1rem;
  padding-bottom: calc(0.75rem + env(safe-area-inset-bottom));
  box-shadow: 0 -4px 16px rgba(0, 0, 0, 0.2);
  z-index: 9999;
}

.mobile-action-grid {
  display: grid;
  grid-template-columns: 1fr 1fr;
  gap: 0.75rem;
  max-width: 600px;
  margin: 0 auto;
}

@media (max-width: 768px) {
  .mobile-action-bar {
    display: block;
  }
}

/* 12. Footer */
.site-footer {
  background-color: #0F172A;
  color: #94A3B8;
  padding: 4rem 0 2rem 0;
  border-top: 1px solid #1E293B;
  font-size: 0.95rem;
}

.site-footer h4 {
  color: #F8FAFC;
  font-size: 1.1rem;
  margin-bottom: 1rem;
}

.site-footer ul {
  list-style: none;
}

.site-footer ul li {
  margin-bottom: 0.6rem;
}

.site-footer ul a {
  color: #94A3B8;
}

.site-footer ul a:hover {
  color: #38BDF8;
}

.footer-grid {
  display: grid;
  grid-template-columns: repeat(auto-fit, minmax(220px, 1fr));
  gap: 2.5rem;
  margin-bottom: 3rem;
}

.footer-disclaimer-card {
  background-color: #1E293B;
  border-radius: 8px;
  padding: 1.5rem;
  margin-bottom: 2.5rem;
  border-left: 4px solid var(--color-accent);
}

.footer-disclaimer-card p {
  margin: 0;
  color: #CBD5E1;
  font-size: 0.9rem;
  line-height: 1.5;
}

.footer-bottom {
  border-top: 1px solid #334155;
  padding-top: 1.5rem;
  display: flex;
  align-items: center;
  justify-content: space-between;
  flex-wrap: wrap;
  gap: 1rem;
}

/* 13. PRINT MEDIA STYLESHEET */
@media print {
  body {
    background: #FFFFFF !important;
    color: #000000 !important;
    font-size: 14pt !important;
    padding: 0 !important;
  }
  .site-header, .site-footer, .emergency-strip, .breadcrumbs-bar, .mobile-action-bar, .content-sidebar, .modal-close, button, input, .card:not(#doctor-modal) {
    display: none !important;
  }
  .modal-overlay {
    position: static !important;
    display: block !important;
    background: none !important;
    padding: 0 !important;
  }
  .modal-box {
    box-shadow: none !important;
    max-width: 100% !important;
    padding: 0 !important;
    border: none !important;
  }
}